Journal of Drug Discovery and Therapeutics

Journal of Drug Discovery and Therapeutics

Basic info

  • Publisher: JDDT
  • Country of publisher: india
  • Date added to EuroPub: 2017/May/09

Subject and more

  • LCC Subject Category: Biomedicine, Anatomy, Pharmacology, Physiology
  • Publisher's keywords: Biomedicine, Physiology, Anotomy, Pharmacology
  • Language of fulltext: english
  • Full-text formats available: PDF

Publication charges

  • Article Processing Charges (APCs): Yes 1000 INR
  • Submission charges: No
  • Waiver policy for charges? No

Editorial information

Open access & licensing

  • Type of License: Other
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2013
  • Does the author retain unrestricted copyright? True
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: None
  • Content digitally archived in: LOCKSS
  • Deposit policy registered in: None

This journal has '285' articles

Chemical composition of volatile extract of Gnaphaliumluteo-album l. Its and its antibacterial activity

Chemical composition of volatile extract of Gnaphaliumluteo-album l. Its and its antibacterial activity

Authors: PoonamKushwaha| Department of Chemistry, DSB Campus, Kumaun University, Nainital, India., Darshan Singh| Department of Chemistry, DSB Campus, Kumaun U...
( 25 downloads)
Abstract

The quantitative and qualitative analysis of the oil by GC and GC-MS, led to the identification of 14 constituents, constituting 96.13 % of the volatile extract.It was mainly characterized by the dominant presence of hydrocarbons (41.6 %) followed by oxygenated sesquiterpene (25.1 %). Dodecane (31.10 %) was found as major compound with other major constituents6,10,14-trimethyl-2-pentadecanone (18.23 %), indol (8.12 %), 5-methyl undecane (7.99 %), γ-cuprene (7.03 %) and isoledene (6.05 %). The antimicrobial activity of the volatile extract was determined by well diffusion method. The extract was found to be significantly active for Klebsiellapneumoniae, Salmonella entericaandEscherichia coli and can be used as antimicrobial agent for these strains. High antibacterial activity of the oil against all microorganismsindicates good bioactive potential of the oil.

Keywords: null
A rare case of flupirtine induced loss of speech.

A rare case of flupirtine induced loss of speech.

Authors: Niroop Revannasiddaiah| Assistant Professor, Department of Pharmacology, PES Institute of Medical Sciences and Research., Chandani Ashok Kumar| Assist...
( 27 downloads)
Abstract

Anarthria can be caused by CNS depressant drugs but flupirtine consumption leading to it, is not documented till date. Since it is a drug with unique properties and is being more commonly used by practitioners, caution needs to be taken in noting rare adverse effects. In this short communication, a case of flupirtine induced loss of speech is reported.

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Formulation and evaluation of tramadol and diclofenac sodium multimodal sustain release tablet dosage form

Formulation and evaluation of tramadol and diclofenac sodium multimodal sustain release tablet dosage form

Authors: Rajesh Asija*| Maharishi Arvind Institute of Pharmacy, Jaipur-302020, Rajasthan, India, Sampat Lal Sharma| Maharishi Arvind Institute of Pharmacy, Jai...
( 109 downloads)
Abstract

Pain is treated using the unimodal pain management which are based on either central analgesic drug mechanism or other drug like nsaid. These drugs control the pain by central nervous system or peripheral nervous system. But in body both system involve for the pain so for moderate to severe pain unimodal approach is not sufficient to address multimodal mechanism. But when we add peripheral anti-inflammatory drug then this multimodal drug combination provides pure pain relief for the treatment. Which prohibit ascending and descending modulation pain pathway message is inhibited by the opioid analgesics and at the site of injury where peripheral nocicepter and peripheral nerve present there NSAID require to relive the pain. Here tramadol and diclofenac sodium tablet is preparing by wet granulation method and evaluated for various parameter like thickness of the tablet, hardness, weight variation cor uniformity, friability to solve transportation problem, drug content for evaluation. Drug release was carried out using USP type II apparatus at 80 rpm in 900ml of dissolution media for 10 hrs. Mean dissolution time is used to evaluate drug release rate from a dosage form and indicates the drug release retarding efficiency of polymer. Tramadol hydrochloride and diclofenac sodium tablet were close to first order release system. HPMC-15 is here using for sustain release of the tablet which provide long therapeutic action of the table for 10 to12 hour Dicalcium phosphate is add as a diluents. For osteoarthritis and rheumatoid arthritis and post surgical, pain, fracture, dislocation, tooth extraction and tooth carries this tablet will vary helpful for long time action and powerfully drug action. Unlikely patient compliance will also increase because the less repetition of dose administration is required.

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Predisposing factors and common clinical presentation of Psoriasis in rural population of Western Maharashtra.

Predisposing factors and common clinical presentation of Psoriasis in rural population of Western Maharashtra.

Authors: Shelke Umesh S*| Undergraduate Student, Department of Pharmacology, Rural Medical College (PIMS-DU), Loni, Ahmednagar,, Narwane Sandeep P| Assistant P...
( 34 downloads)
Abstract

Introduction: Psoriasis is a non-contagious inflammatory skin disorder characterized by dry, erythematous, scaly plaques that develops over various parts of body. Prevalence of psoriasis is 0-11.8% around the globe which varies from region to region and increasing globally. Its clinical presentation also varies depending upon the environmental, hereditary and various other predisposing factors. Knowledge of common clinical presentations and predisposing factors is essential in prevention, early diagnosis and treatment. Objectives: To study the predisposing factors and common clinical presentations of psoriasis in patients. Methods: A modified, pre-tested, semi-structured Psoriasis Evaluation plus Medication survey questionnaire was used in patients of psoriasis presenting to the skin department of Pravara Rural Hospital, Loni this study. Results: Proportion of psoriasis was high in males of 20-40 years with positive family history. There was no significant association psoriasis with addiction. Psoriatic patches were of non-red, thickened, scaly in nature commonly observed on leg, forearm and scalp. The involvement of fingernail, toenail and combination of both along with Psoriatic arthritis was significantly higher in males. Conclusion: Male predominance, family history is the common predisposing factors which are found to be associated with Psoriasis. There is involvement of 1-3 regions of body and non-red, thickened, scaly type of pattern of psoriasis is seen in psoriatic patients of rural western Maharashtra, which may be helpful in prevention and early detection of psoriasis.

Keywords: null
Formulation and Evaluation of Nanosilver Loaded Silk Fibroin Topical Gel

Formulation and Evaluation of Nanosilver Loaded Silk Fibroin Topical Gel

Authors: Rajesh Asija*| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Rajasthan, India, Avinash Gupta| Depart...
( 35 downloads)
Abstract

The skin is providing barrier to the outside protecting the body from infection, radiation, and extremes of temperature. There are various types of wounds which can damage the skin including abrasions, lacerations, rupture injuries, punctures, and penetrating wounds. Many of the wounds are superficial requiring local first aid including cleansing and dressing. But some wounds are deeper and need medical attention to prevent infection and loss of function, due to damage to underlying structures like bone, muscle, tendon, arteries and nerves. The purpose of medical care for wounds is to prevent complications and function. While important, cosmetic results are not the primary consideration for wound repair. Wound healing, a common clinical entity contemporary to human beings, most often susceptible to microbial infection. The ultimate goal for wound healing is a speedy recovery with minimal scarring and maximal function. Different approaches such as use of antimicrobials and cell growth promoting agents have been used for achieving the set goal. Silk fibroin, a cell growth promoter has been used as wound healing agent. Out of the present antimicrobial agents silver nanoparticles exhibit broad spectrum of anti-microbial activity. The mono dispersed silver nanoparticles with narrow particle size distribution are more effective anti bacterial agents, because of high surface/volume fraction, so that large populations of silver atoms are in direct contact with the environment. Silver Nanoparticles are non toxic to human cell to the tune of 350µg/day.

Keywords: null
BILATERAL CONGENITAL GLAUCOMA IN NEUROFIBROMATOSIS TYPE 1 AND MANAGEMENT. (A RARE - CASE REPORT)

BILATERAL CONGENITAL GLAUCOMA IN NEUROFIBROMATOSIS TYPE 1 AND MANAGEMENT. (A RARE - CASE REPORT)

Authors: Dr G. D. Channashetti*| Glaucoma Fellow, Aravind Eye Care Hospitals, Madurai, Tamilnadu, India., Dr S. S. Kottagi| Department of Biochemistry, Shri B...
( 52 downloads)
Abstract

Neurofibromatosis 1 is a genetic disorder of neural crest-derived cells. Riccardi classified NF into 8 subtypes NF-I to NF-VIII. NF-V is segmental NF (Prevalence 0.0014 and 0.002%) Caused by a Postzygotic somatic mutation, Café-au-lait macules & neurofibromas in a single, unilateral segment of the body, no family history, no systemic involvement. SNF classified into true segmental & Bilateral SNF. Glaucoma is a rare manifestation ofNeurofibromatosis -1. Patients usually have cafeaulait spots, plexiform neurofibroma of upper lid, and axillary freckles. If plexiform neurofibroma is present a 50% chance of developing glaucoma exists. Glaucoma is always unilateral, usually exists at birth or shortly after birth. We present a case of bilateral congenital glaucoma in Neurofibromatosis type 1 and management.

Keywords: null
OPHTHALMOMYIASIS EXTERNA CAUSED BY SHEEP BOTFLY (OESTRUS OVIS) LARVA: RARE CASE REPORT

OPHTHALMOMYIASIS EXTERNA CAUSED BY SHEEP BOTFLY (OESTRUS OVIS) LARVA: RARE CASE REPORT

Authors: Dr G. D. Channashetti*| Department of Ophthalmology, Shri B M Patil Medical College, Bijapur, Karnataka, India., Dr S. S. Kottagi| Department of Bioch...
( 48 downloads)
Abstract

Ophthalmic myiasis is due to deposition of fly larvae in the human eye. Various species of flies are able to provoke ophthalmomyiasis, including, Oestrus ovis , latrine fly (Fannia), house fly (Musca domestica), and cattle botfly (Hypoderma).14,15 Oestrus ovis is by far the most common cause of ophthalmic myiasis in man.8 Ophthalmic myiasis due to Oestrus ovis was described for the first time in 1947 by James.

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Life threatening ventilatory obstruction due to a foreign body in a new sealed endotracheal tube

Life threatening ventilatory obstruction due to a foreign body in a new sealed endotracheal tube

Authors: Padara Basavaraj| Assistant Professor Department of Anaesthesiology , BJ Medical College and Sassoon Hospital Pune, Maharastra, India., Jamkar MA| Ass...
( 43 downloads)
Abstract

In the current days of high tech equipment and well defined safety regulations, technical failures are less likely to occur. Still many manufacturing and packaging errors are encountered in anaesthetic practice which go unnoticed during the routine inspection prior to their use. A 32 year old healthy adult male with insignificant medical and surgical history was posted for clavicular plating under general endotracheal anaesthesia (GETA).

Keywords: null
Radiocarbon dating: a scientific overview

Radiocarbon dating: a scientific overview

Authors: Jesika Chandan Rane| Assistant Professor, Department of Quality Assurance, K.Y.D.S.C.T., College of Pharmacy, Sakegaon, Bhusawal, India
( 26 downloads)
Abstract

The review provides scientific and basics view on radiocarbon dating. However, his presentation, calibration and interpretation of radiocarbon ages are misleading in some cases, and important wide applications for age determining process. Radiocarbon dating is a radiometric dating method that uses the naturally occurring radioisotope carbon-14 (14C) to estimate the age of carbon-bearing materials up to about 58,000 to 62,000 years.

Keywords: null
A study on clinical profile of abrus precatorius poisoning in R.M.M.C.H

A study on clinical profile of abrus precatorius poisoning in R.M.M.C.H

Authors: Dr. N.Karthikeyan| Postgraduate student,Department of Emergencies Medicine, Rajah Muthiah Medical College, Annamalai University, India, Dr. P.Swaminat...
( 39 downloads)
Abstract

Self harm has often been thought of as a problem particular to the industrialized worldIt is clear from many studies that not all people who die following acts of self-harm actually wish to die. Instead, the acts are used to express rage or hostility, or to gain revenge by causing distress to another personMany factors affect the outcome, including the degree to which the poison's toxicity was understood, the speed with which the person comes to clinical attention, and the availability of effective medical treatment.Our objective is to find out The incidence and clinical presentation of Abrusprecatorius poisoning in Emergency room R.M.M.C.H.This study was conducted in 30 patients who were admitted to Rajah Muthiah Medical College Hospital with alleged history of consumption of seeds of Abrusprecatorius poisoning, from July 2012 to June 2014.The male: female ratio was 1:4. This shows that females indulge themselves in greater number in deliberate self-harm.Hypokalemia was noted in 40% of patients included in this study, which was only mild. This is probably secondary to excess fluid loss. This fact is also supported by the study done Fernando C.The major symptoms of abrus poisoning include vomiting 100% and diarrhea 67% that may become bloody. Severe dehydration may be the result, followed by low blood pressure. Other signs or symptoms may include hallucinations, seizures, and blood in the urine 33%. Within several days, the person's liver, spleen, and kidneys might stop working, and the person could expired.Approximately 7% of the patients may die following ingestion of these plant seeds.

Keywords: null
A review on oral dispersible tablet

A review on oral dispersible tablet

Authors: Rajesh Asija*| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Rajasthan, India, Avinash Gupta| Depart...
( 33 downloads)
Abstract

It has been reported that about 40% of the compounds being developed by the pharmaceutical industries are poorly water soluble. The limiting factor to the in vivo performance of poorly water soluble drugs after oral administration their inadequate ability to be wetted by and dissolved into the fluid in the gastrointestinal (GI) tract. Therefore, increasing the dissolution rate of poorly water soluble drugs is an important and significant challenge to pharmaceutical scientists in order to maximize absorption. Commercially used processes are spray drying, mechanical milling, formation of solid dispersion, and freeze drying. Aceclofenac is a nonsteroidal anti-inflamatory drug (NSAID), used for rheumatoid arthritis, osteoarthritis and other joint pains. Aceclofenac is often used orally. The oral bioavailability of aceclofenac was found to be very poor likely due to the very poor dissolution in aqueous fluids especially in acidic mediums. The studyi utilized of the solvent evaporation method for preparation of stable amorphous solid dispersions of Aceclofenac by adsorbing it on porous carrier (Florite).

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Pharmacovigilance in psychiatry: time to take notice

Pharmacovigilance in psychiatry: time to take notice

Authors: Arghya Pal| All India Institute of Medical Sciences, New Delhi, India., Atul Ambekar| All India Institute of Medical Sciences, New Delhi, India., Saga...
( 33 downloads)
Abstract

The term ‘Pharmacovigilance’ is used to describe the activities that are related to monitoring adverse drug reactions (ADRs). The World Health Organization (WHO) defines it as “the science and activities relating to the Detection, Assessment, Understanding and Prevention of adverse drug reactions or any other possible drug related problems”.

Keywords: null
A review on pathophysiology and treatment of aplastic anaemia

A review on pathophysiology and treatment of aplastic anaemia

Authors: Jyoti Nayak*| Department of Pharmacology, Rameshwaram Institute of Technology & Management, Lucknow, U.P., India, Akanksha Singh| Department of Pharma...
( 35 downloads)
Abstract

Aplastic anaemia is a medical condition in which the bone marrow is fails to make enough blood cells such as RBC, WBC & Platelets. It is mostly 2 types such as acquired and inherited and it is caused by exposure to chemicals (benzene and some carbmates), radiation (U.V), Drugs (Choramphenicol, carbamezepines etc), infection (virus) and immune disease. In aplastic anaemia diagnosis can be confirmed by bone marrow examination and it can be treated by immunosuppressive therapy, marrow stimulating agents and if aplastic anaemia is severe so used bone marrow transplantation.

Keywords: null
STUDIES ON PHENOTYPIC TRAITS AND GENETIC VARIABILITY IN ERG 11 GENE AMONG DRUG RESISTANT CANDIDA SPECIES

STUDIES ON PHENOTYPIC TRAITS AND GENETIC VARIABILITY IN ERG 11 GENE AMONG DRUG RESISTANT CANDIDA SPECIES

Authors: Surabhi Kaura*| Departement of Microbiology, Shoolini Institute of Life Science and Business Management, Solan, India, Surjeet Singh| Departement of M...
( 45 downloads)
Abstract

Candida is an opportunistic pathogen of human beings and other mammals. It is the leading agent of various types of diseases in immunocompromised individuals. The most common infecting species is C. albicans where as other non albicans species are C. glabrata, C. parapsilosis, C. tropicalis and C. krusei also causes various clinical diseases. Candidemia is the fourth leading cause of bloodstream infections and carries a 35–55% mortality. The widespread use of azoles has led to increasing azole resistance among Candida albicans strains. One mechanism of azole resistance involves point mutations in the ERG11 gene, which encodes the target enzyme (cytochrome P450 lanosterol 14α-demethylase). Aim of study was to isolate azole-drug resistant Candida species and to observe genetic variability in ERG11 gene, also phenotypic characterization of different Candida species. In the present study, 24 strains were examined for phenotypic characters such as the pseudohyphae, chlamydospore formation and germ tube production and some colored colonies on chrome agar. Antifungal susceptibility testing was also done by placing fluconazole and voriconazole disk on Muller Hinton agar. Zone of inhibition of various diameters were formed around these disks by which we identified resistant and sensitive Candida sp. Two isolates of Candida tropicalis were resistant to both the antifungal agents. The ERG 11 gene of two azole drug resistant isolates was then amplified using forward and reverse primers. The two drug resistant amplified products were then sequenced and the sequence results were compared with homologous species.

Keywords: null
COMPARISON OF LABORATORY METHODS FOR THE DIAGNOSIS OF URINARY TRACT INFECTION

COMPARISON OF LABORATORY METHODS FOR THE DIAGNOSIS OF URINARY TRACT INFECTION

Authors: Dr. Sanjay D Rathod| Associate Professor,Department of Microbiology, Smt. NHL Municipal Medical College, Ahmedabad, India, Dr. Dipti D Patel| 2ndYear...
( 50 downloads)
Abstract

Introduction: Urinary Tract Infection (UTI) is most frequent bacterial infection.Conventional urine culture is widely used for its diagnosis. This method is time consuming, expensive and patients are often treated before results are available. Dipsticks Nitrite Test (NT), Leucocyte Esterase (LET) and microscopic examination are commonly used primarily to predict the outcome of urinary tract infection. Objective: To compare reagent strip testing with microscopy and culture on different medias to identify significant bacteriuria. Methods: 500 samples were tested by semi-quantitative culture on cysteine lactose electrolyte deficient agar (CLED) with Andrade indicator, Mac conkey agar , Nutrient agar, microscopic examination of urine for significant pyuria, dipstick LET and NT. Culture was used as gold standard to evaluate the performance of direct microscopy and dipstick tests Results: Out of 500 urine sample 162(32.4%) were culture positive , out of these 162 samples 100(61.7%) samples showed significant bacteriuria (>105 CFU/ml). Sensitivity, specificity, positive predictive value (PPV)and negative predictive value (NPV)of the dip-stick LET were 71.6%, 75.7%, 58.5%, and 84.7% respectively; those of the dip-stick NT were 59.2%, 84.0%, 64%, and 81%respectively; and those for microscopic significant pyuria detection were 66%, 81.3%,62.9% and 83.3% respectively. Highest sensitivity (87.6%) and NPV (93.1%) was obtained on combining microscopy and dip-stick LET and NT . Escherichia coli was the most common organism isolated (n75=46.3%). Conclusion: Study suggests that positive cultures cannot be accurately predicted by single method, but Combined use of all three methods have > 90% prediction (NPV) for negative culture. Use of CLED agar with Andrade indicator proven to be useful as primary medium & helped to reduce the plate burden & work load.

Keywords: null

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