International Research Journal of Applied and Basic Sciences

International Research Journal of Applied and Basic Sciences

Basic info

  • Publisher: Science Explorer Publications
  • Country of publisher: united kingdom
  • Date added to EuroPub: 2017/May/14

Subject and more

  • LCC Subject Category: Public Health and Community Medicine
  • Publisher's keywords: Health
  • Language of fulltext: english
  • Time from submission to publication: 8 weeks

Publication charges

  • Article Processing Charges (APCs): No
  • Submission charges: No
  • Waiver policy for charges? No

Open access & licensing

  • Type of License: CC BY
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2010
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: None
  • Content digitally archived in: LOCKSS, CLOCKSS
  • Deposit policy registered in: None

This journal has '2582' articles

IbneFarshid and the mystical "Haghighat Mohammadi"

IbneFarshid and the mystical "Haghighat Mohammadi"

Authors: Parivash Malaki| M.A. Arab Language and Literature, Islamic Azad University of Garmsar-Iran, email: [email protected]
Year: 2017, Volume: 11, Number: 2
(79 downloads)
Abstract

Ibn Farez Egyptian is the greatest poet of Arabic and contemporary Ibn Arabi, he has been nicknamed Sultan alAlashakin. His poetry is the culmination of the mystic language and mystical experiences. His Divan is, despite the small volume of the most famous Arabic dialects, in which there are many outstanding mystical concepts that contain the material and truth that Allah Almighty in the hearts of the believers and others Bonded. One of these stories is a Mohammadi truth in order to better understand and recognize the pleasures and truths that this mystic has achieved and speaks of it in poetry.The importance of the mystical themes of the poetry of Ibne Farz is enough to be explained and interpreted by the great mystics such as Qaisari, Ibn T?rek, Jami and Farghani, as well as Sheikh Hasan alBourini (1024 AH, 1615 AD), based on apparent meanings His Divan has a literary, literary, and scriptural account, and the most famous Sufi description of this is Abdul Ghani AlNabaldi (1143, 1730). And Rashid ibn Ghalib alDahadah combines the two abovementioned descriptions, and his book has been published on many occasions. Therefore, the analysis of this process is necessary. In this article, through reflection on the biographies of "Ibn FarzaseMasri" and his poems, he examined the "truth of Mohammadi".

Keywords: Ibn Farez, Mostaelh Erfani, Haghighat Mohammadi, Spirit
Impact of Finasteride Administration on Neuroactive Steroid Levels To Induce Persistent Sexual Side Effects and Anxious/Depressive Disorders and the Possible Protective Effect of Vitamin E

Impact of Finasteride Administration on Neuroactive Steroid Levels To Induce Persistent Sexual Side Effects and Anxious/Depressive Disorders and the Possible Protective Effect of Vitamin E

Authors: Sahar Youssef, Sahar Badr El- Din Mohamed
Year: 2017, Volume: 11, Number: 2
(2 downloads)
Abstract

Background: With aging, abnormal benign growth of the prostate results in benign prostate hyperplasia (BPH) with concomitant lower urinary tract symptoms. Because the prostate is an androgen target tissue, and transforms testosterone into 5α-dihydrotestosterone (5α-DHT), a potent androgen, via 5α-reductase (5α-R) activity, inhibiting this key metabolic reaction was identified as a target for drug development to treat symptoms of BPH. Nowadays, Finasteride is a relatively frequently prescribed drug in the therapeutic management of BPH and male androgenic alopecia. Conflicting reports have led to two diverse and contradictory recommendations from the use of Finasteride. Histopathologic assessment of the testis is a vital component of drug safety evaluation. The reported adverse effects are notable in some patients, consisting in signs and symptoms that are encountered both during Finasteride administration and after treatment cessation. It is well known that brain and plasma levels of the neurosteroid allopregnanolone (ALLO) increase after acute environmental stress, fact that has been considered a homeostatic mechanism in restoring normal function following stress. Thus, it is of great interest to study the contribution of stress-altered plasma ALLO levels and administration of Finasteride (an ALLO synthesis inhibitor). Clinical data show that cognition and sexuality are two distinct but interrelated environmental functions, most probable due to lateralization process of the brain. Aim: This study was carried out to evaluate the changes of neuroactive steroid ALLO Level in Finasteride treated rats and its relation to induce persistent sexual side effects and anxious/depressive symptoms. The possible protective role of vitamin E was also investigated. Materials and Methods: Forty adult male rats divided into four equal groups: group I which served as the control group; group II, Finasteride group which received Finasteride daily at a dose of 5mg/kg/day; group III, Vitamin E group which received only Vitamin E at a dose of 100 mg/kg bodyweight. Group IV, Finasteride and vitamin E group received Finasteride at a dose of 5mg/kg/day alongside with Vitamin E at a dose of 100 mg/kg. Treatments were administered orally by gavage for 28 days. At the end of the experimental period, the markers of oxidative stress were investigated. The animals were submitted to swim stress test for evaluation of depressive like behavior and estimate the plasma ALLO level before and after acute swimming test. Moreover, the histological and the immunohistochemical changes occur in the rat testes were investigated. Results: Administration of Finasteride showed substantial changes in the seminiferous tubules with loss of the normal architecture. The spermatogenic cells were disorganized, degenerated, and separated from the underlying basement membranes. Some areas of interstitium were wide with congested blood vessels and extensive areas of hemorrhage can also be observed. The immunohistochemical study showed a decrease in the intensity of AR immunostaining in Sertoli, Leydig, and peritubular myoid cells and in the number of PCNA immunopositive germ cells in comparison with control. Co-administration of vitamin E with Finasteride induced improvement in testicular histological changes as well as increase in the number of AR and PCNA immunopositive cells. The immunohistochemical expression of Bax protein was high in the Finasteride group. The Bax expression was low in the control and vitamin E groups. Co-treatment with vitamin E and Finasteride displayed moderate expression on the immunoractivity of Bax. Statistically, There are significantly reduced levels of GSH, SOD and CAT (P˂0.001) with increased in MDA concentration (P˂0.001) in Finasteride treated group compared to control group. While, vitamin E treated group, there is significantly change compared to Finasteride group. As regards the ALLO plasma level, it was found that in Finasteride treated rats (group II); significantly decrease this level when compared with the control. In vitamin E treated rats, there was significant increase when compared with group II. However, there was no significant change in rats taken Finasteride and vitamin E (group IV) when compared with group II. Also, the same result obtained after the animals exposed to stress swim test. The current study demonstrated that vitamin E cannot completely ameliorate the adverse effects of Finasteride but it diminished to some extent the deteriorating changes observed in testicular tissues. Conclusion: Finasteride induced harmful effects in the testicular tissues and CNS. Concomitant administration of vitamin E caused partial improvements.

Keywords: Finasteride, ALLO, CNS, PCNA, AR, Bax, Rat, Testes, Vitamin E

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