Asian Pacific Journal of Health Sciences

Asian Pacific Journal of Health Sciences

Basic info

  • Publisher: IJPMR Publishing Press, India.
  • Country of publisher: india
  • Date added to EuroPub: 2019/Sep/29

Subject and more

  • LCC Subject Category: Medicine, Health and Wellness
  • Publisher's keywords: Medicine, Health
  • Language of fulltext: english
  • Time from submission to publication: 6 weeks

Publication charges

  • Article Processing Charges (APCs): No
  • Submission charges: No
  • Waiver policy for charges? No

Open access & licensing

  • Type of License: CC BY
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2014
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: Other
  • Deposit policy registered in: None

This journal has '459' articles

Adherence to hypertension management and lifestyle modifications in patient attending general practice outpatient department in tertiary care hospital of eastern Nepal

Adherence to hypertension management and lifestyle modifications in patient attending general practice outpatient department in tertiary care hospital of eastern Nepal

Authors: Pramendra Prasad Gupta
Year: 2018, Volume: 5, Number: 1
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Abstract

Background: Hypertension is a huge problem worldwide. It should be managed with a combination of lifestyle modifications and medication. The objective was to find out the level of understanding of hypertensive patients regarding lifestyle modifications; to find their level of application in their daily activities, and to study their effects on the management of hypertension. Methods: We conducted an observational study with hypertensive patients who presented to GOPD at BPKIHS. We assessed the level of knowledge of those patients with a structured survey. Patients were told about lifestyle modifications following Joint National Committee 7 Guidelines. Patients were reassessed using the same survey at 1 month and 3-month follow-up. Results: Among the 100 patients included, 6% had prehypertension and 94% had Stage 1 or 2 hypertension. Only 26% of patients knew about lifestyle modifications. After being told about lifestyle modifications, 89% stated that they had adopted them at follow-up. 68 patients came for 1-month follow-up and 51 patients for 3-month follow-up. There was significant weight reduction: Average weight loss 3.54 kg over 3 months (P < 0.001). At 1-month the percentage of subjects with controlled hypertension was 13.2% and at 3 months follow-up it fell to 2% (P < 0.001). 71% patients’ blood pressure (BP) was controlled without medication at 1-month and 77% at 3 months. Conclusion: A minority of patients knew about lifestyle modifications. After counseling, their implementation was associated with weight reduction and improved control of BP. Good lifestyle counseling is a crucial and effective part of hypertension management.

Keywords: Exercise, hypertension, lifestyle modifications
Inter-relationship of calcium, Vitamin D, and fluoride in periodontal health: An overview

Inter-relationship of calcium, Vitamin D, and fluoride in periodontal health: An overview

Authors: A Bey
Year: 2018, Volume: 5, Number: 1
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Abstract

Many dental diseases are the result of developmental and maturation defects of teeth. Few of them are prenatal and postnatal calcification defects, developmental disturbances due to endocrine abnormalities, influence of dietary factors, mottled and hypoplastic enamel, caries, and loose teeth. Calcium is considered an important element for the proper development and maintenance of calcified dental tissues and the body; however, knowledge its role in the development and progression of periodontitis is very important. In this review, article general concepts of diet, nutrition, and relationship between calcium and periodontal disease have been discussed.

Keywords: Calcium, hypoplastic enamel, periodontal disease, postnatal calcification, Vitamin D
Knowledge of tuberculosis and prevalence of return after default and treatment failure among patients on directly observed treatment short course therapy at Specialist Hospital, Sokoto, Nigeria

Knowledge of tuberculosis and prevalence of return after default and treatment failure among patients on directly observed treatment short course therapy at Specialist Hospital, Sokoto, Nigeria

Authors: SA Mora
Year: 2018, Volume: 5, Number: 1
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Abstract

Background: Tuberculosis (TB) is a major public health problem in Nigeria, and the TB burden is further compounded by the high prevalence of human immunodeficiency virus in the country. This study was conducted to assess the knowledge of TB and prevalence of return after default and treatment failure among patients on directly observed treatment short course (DOTS) therapy at Specialist Hospital, Sokoto, Nigeria. Materials and Methods: A cross-sectional study was conducted among 75 patients on DOTS for TB. Data were collected with a set of structured interviewer-administered questionnaire. Data on patients’ treatment profile were also extracted from their case files and entered into a proforma. Results: A larger proportion 32 (42.6%) of the 75 patients were aged 21–30 years. Majority of respondents 58 (77.3%) had adequate knowledge of TB, and it was significantly associated (P < 0.05) with having secondary and tertiary education. Ten (13.3%) of the 75 respondents have ever stopped taking their anti-TB drugs during the course of their treatment. Of these, majority 6 (60.0%) attributed it to forgetfulness. None of the respondents had treatment failure or fulfilled the criteria to be categorized as return after default. Conclusion: This study showed a high level of knowledge of TB, good compliance with treatment, and absence of return after default and treatment failure among the study participants. These findings underscore the pivotal role of education of members of the public and patients in facilitating appropriate health-seeking behavior, compliance with treatment, and favorable treatment outcome.

Keywords: Knowledge, prevalence, return after default, treatment failure, tuberculosis
Buccal fat pad graft in oral and maxillofacial surgery-A review

Buccal fat pad graft in oral and maxillofacial surgery-A review

Authors: Kumar R
Year: 2018, Volume: 5, Number: 4
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Abstract

Buccal fat pad is much underutilized graft in oral and maxillofacial surgeries. Although, it has been recognized in early seventeenth century, but its use in different conditions as a graft was popularized after mid eighteenth. This article encompasses various aspects of buccal fat pad including its anatomy, development, clinical significance and uses as a graft in much reconstructive procedures in oral and maxillofacial surgery cases e.g. Oroantral fistula, oral sub-mucous fibrosis, resections, reconstructions cases.

Keywords: Buccal fat pad, graft, Oroantral fistula, oral sub-mucous fibrosis, resections, reconstructions.
A clinical study On Changes in oxygen saturation, haemodynamics and ECG in patients during postoperative period undergoing abdominal surgery using different analgesic regimens

A clinical study On Changes in oxygen saturation, haemodynamics and ECG in patients during postoperative period undergoing abdominal surgery using different analgesic regimens

Authors: KB. Mishra
Year: 2018, Volume: 5, Number: 4
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Abstract

Patient generally faces some degree of cardio-pulmonary complication, in post operative period, measuring O2 saturation, ECG changes and haemodynamics changes despites pulmonary and circulatory complication in post operative patient receiving Morphine, Tramadol and Pathedine. Patients were divided into 3 groups. Group A: Morphine Group -: Subgroup I: morphine IM, Subgroup II: morphine IV, Subgroup III: Morphine epidurally, Group B: Tramadol Group -: Subgroup I: tramadol IM, Subgroup II: tramadol IV, Subgroup III: Tramadol epidurally., Group C: Control Group-: Patients receiving Pethidine IM on demand, which is the standard practice. In each .sub group we 10 patient included (n=10).In our study we found Variables like pulse rate, systolic or diastolic or mean blood pressure, respiratory rate, changes in ECG and arterial oxygen saturation showed no statistically significant difference between study and control groups. Keeping in view all the factors considered in the present study, epidural morphine was found to be the best analgesic with very good analgesia, less sedation and hemodynamic stability with fewer side effects. Epidural Tramadol was found to be the next best. IM Tramadol was last in rating as it was a poor analgesic for intense postoperative pain, although hemodynamic and respiratory stability was good without any side effects. So we recommend epidural morphine 3mg in 10ml saline for control of postoperative pain relief.

Keywords: tramadol, hemodynamic, patient
To Study the Etiology and Predicting Scores of Patients with acute on chronic liver failure

To Study the Etiology and Predicting Scores of Patients with acute on chronic liver failure

Authors: Rachit Magazine
Year: 2018, Volume: 5, Number: 4
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Abstract

Aim: To study the aetiology, precipitating insults of patients presenting with acute on chronic liver failure and predictors of mortality of acute chronic liver failure. Methods: The prospective study was carried out in 100 patients admitted with acute on chronic liver failure for a period of 1 year in the Department of Medicine of Government medical college and Hospital, Jammu. Results: ACLF has a predominant male preponderance i.e 92 %. The mean age of patients presenting with ACLF was 45.39 ± 1.1 yrs. Among causes of chronic liver disease alcohol was commonest (79 %) followed by Alcohol + Hepatitis C (4.0 %) ,Alcohol + hepatitis B (1 %), Hepatitis B (1 %), Hepatitis C (3 %), NASH related (4 %) and Auto immune (5 %).Etiologyof acute precipitants included alcohol (43%) followed by Alcohol with Hepatitis B/C (9 %), alcohol with Hepatitis E (4%), alcohol with hepatitis E + Dengue (2%), Hepatitis E (8%), Hepatitis B (8 %) and Hepatitis C (6%) ,Hepatitis E + Leptospirosis (2%), leptospirosis (1%) and gastrointestinal bleed + others etiology (14%) were other causes of acute etiology in patients of acute on chronic liver failure. The mean SOFA, MELD and MDF scores were found to be better predictors of mortality. Conclusion: ACLF carries a high mortality rate. Alcohol was found to be the most common cause of chronic etiology of Chronic liver disease as well as acute insult. Scoring systems such as SOFA, MELD and MDF scores were considered to better predictors of mortality.

Keywords: Alcohol, Chronic Liver failure, etiology, mortality.
The Crown Lengthening Surgery: Two Case Reports

The Crown Lengthening Surgery: Two Case Reports

Authors: Samiran Sinha
Year: 2018, Volume: 5, Number: 4
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Abstract

Clinical crown of the tooth is the distance from gingival margin to incisal edge or occlusal surface of the tooth. Crown lengthening is a surgical procedure designed to increase the extent of the supragingival tooth structure, so that the clinician can restore the tooth. The crown lengthening procedure (CLP) is commonly used to maintain the dentogingival complex in optimal conditions and to correct aesthetic defects through a smile design. The aim of the current case reports is to evaluate the implications of CL in routine dental practice. The diagnosis requirements, procedures of crown lengthening, importance of crown lengthening and esthetic improvements after crown lengthening are discussed in different sessions.

Keywords: Clinical Crown, Crown Lengthening, Dentogingival Complex, Aesthetic.
Study of Flexible Intramedullary Titanium elastic Nail fixation in a Paediatric shaft of Femur fracture

Study of Flexible Intramedullary Titanium elastic Nail fixation in a Paediatric shaft of Femur fracture

Authors: Krishna Sapkota
Year: 2018, Volume: 5, Number: 4
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Abstract

Background: Paediatric shaft of femur fracture account for 1.4 to 1.7 percent of all the paediatric fractures. There are many treatment options for fracture shaft of the femur. Treatment decision depends upon children age, fracture character and social status. Initially, surgical treatments for fracture shaft of the femur were confined to polytrauma patients. Now due to early mobilization, less hospital stay and early return to home and school, treatment tends toward surgery.Aims: The study was done to see the outcome of fracture shaft of femur in paediatric age group with titanium elastic nail.Material and Methods: There were total of 33 patients with fracture shaft of the femur enroll for this study. They all are treated with flexible intramedullary titanium elastic nail fixation. Their outcome was evaluated at different time interval.Statistical analysis: The data was analyzed by using SPSS for Windows (version 16.0) Results: The mean age of patients in this study was 8.70± 2.51 years. All patients had the union of fractures by the end of 7 weeks with excellent outcome seen in 22(66.67%) cases and satisfactory outcome seen in 9(22.27%) cases. Six patients had the poor outcome with acceptable range of deformity and skin irritation.Conclusion: TENS is an easy, cost- effective modality of treatment. Proper patient and case selection provides an excellent outcome.

Keywords: Paediatric shaft of femur fractures, TENS, Flexible nail.
Bilateral benign phyllodes  tumor of breast

Bilateral benign phyllodes tumor of breast

Authors: Kishore Vatsala
Year: 2018, Volume: 5, Number: 4
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Abstract

Phyllodes tumor or cystosarcoma phyllodes are rare type of fibroepithelial breast neoplasms consisiting of 1% of all mammary tumors. They are biphasic in nature and have very low incidence of bilateral occurrence. The median age of presentation is 40-50 years. We present a case of 37 years female with phyllodes tumor developing in both the breasts metachronously with a gap of 5 years.Patient underwent widelocal excision and histopathological report confirmed benign type of cystosarcoma phyllodes in bilateral breasts.

Keywords: cystosarcomaphyllodes, phyllodestumor, bilateral breasts
Repeating Hydrodistension Does Not Improve Symptoms in the Interstitial Cystitis Patients

Repeating Hydrodistension Does Not Improve Symptoms in the Interstitial Cystitis Patients

Authors: Göksel Bayar
Year: 2018, Volume: 5, Number: 4
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Abstract

Objective: To evaluate effect of second hydrodistension on symptoms of patients who have diagnosed interstitial cystitis and have been performed hydrodistension before. Material-Methods: Data of the patients who have diagnosed interstitial cystitis and were performed hydrodistension between June 2015 and June 2017 were retrospectively evaluated. Diagnosis of interstitial cystitis was done on three criteria according to clinical guidelines. Hydrodistension was performed by a single surgeon under spinal anesthesia. The bladder was distended with normal saline through a cystoscope to provide pressure of 80 cmH2O. After hydrodistension for 5 minutes the bladder was evacuated, which might lead to hemorrhage of the apparently normal bladder mucosa (glomerulations). O’Leary–Sant’s symptom and problem index (OS combined), Pelvic Pain and Urgency/Frequency (PUF) Patient Symptom Scale and the Likert visual analog scale (VAS) for pain were used to evaluate the severity of symptoms. After the hydrodistension, patients were followed-up by without medication. Second hydrodistension was performed when symptoms were recurred. Results: Total 17 patients were diagnosed interstitial cystitis. Symptoms of seven patients were not improved by first hydrodistension, so second hydrodistension was not performed to these patients. These seven patients were excluded. Total 10 patients were included the study. Median OS combined (24 vs 20.5 p= 0.356), PUF (33 vs 29 p= 0.113) and VAS (8 vs 7 p= 0.452) score were similar before and after second hydrodistension. Conclusions: Second hydrodistension is not effective in interstitial cystitis patients whom were treated hydrodistension before.

Keywords: Interstitial cystitis, hydrodistension, repeating.
A study on C-reactive protein as an early marker of vasococclusive crisis in sickle disorders

A study on C-reactive protein as an early marker of vasococclusive crisis in sickle disorders

Authors: Dr. Anindya Sasmal
Year: 2018, Volume: 5, Number: 4
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Abstract

Background: Sickle cell disease (SCD) patients often seek care in the Emergency Department (ED) due to vaso-occlusive crisis (VOC), the most common complication of SCD. Currently, no diagnostic test can determine if a SCD patient is having an acute VOC. Methodology: Irrespective of the clinical diagnosis and type of sickle cell crises the confirmation of haemoglobin pattern in sickle cell disease patients and healthy subjects were done by sickling test, hemoglobin electrophoresis or high performance liquid chromatography. Results: Irrespective of age and sex, most common variety of vaso-occlusive crisis was bony crisis including hand foot syndrome. About 91.2% patients demonstrated CRP positivity during the early phase of vaso-occlusive crisis. Subsequently the CRP positivity rate declined in the mid phase (28%) and late phase (2.4%) of vaso-occlusive crisis reflecting response to therapy. There is a significant difference of CRP status between non vasoocclusive and vaso–occlusive crisis of sickle cell disease patients. About 96.3% patients of non vaso-occlusive crisis became CRP negative during their whole course of their crisis. Conclusion: Analysis of large number of cases with sickle cell vaso-occlusive crisis with quantitative serial measurement of CRP level is needed for better evaluation of patients during prodromal phase for effective and better management of these patients.

Keywords: Sickle cell disease, vaso-occlusive crisis, C-reactive protein, marker, sickling test, hemoglobin electrophoresis, high performance liquid chromatography.
Synthesis and Antimicrobial evaluation of Azole Based (p-nitro Benzoic Acid) derivatives

Synthesis and Antimicrobial evaluation of Azole Based (p-nitro Benzoic Acid) derivatives

Authors: Omprakash Sharma
Year: 2018, Volume: 5, Number: 4
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Abstract

This study includes the Synthesis of Azoles Based p-nitro Benzoic Acid Derivative. The compounds were prepared by reaction of p-nitro Benzoic Acid with thiosemicarbazide in the presence of Phosphorus oxychloride to yield 1, 3, 4-thiadiazole nucleus. Further this thiadiazole was treated with different aromatic aldehydes in presence of methanol to yield corresponding Schiff’s bases. All the Schiff’s bases thus obtained were reacted with Thioglycolic acid to yield the title compounds. Synthesized derivatives were characterized by IR, H1NMR and screened for their antibacterial (S. aureus, B. subtilis, E. coli, and P. aerugiosa) and antifungal activity (A. Niger and C. albicans).

Keywords: Azole derivative, p-nitro Benzoic Acid derivative, antimicrobial activity.
Azadirachta indica – Therapeutic Potential in Oro Dental Conditions

Azadirachta indica – Therapeutic Potential in Oro Dental Conditions

Authors: Anjana Goyal
Year: 2018, Volume: 5, Number: 4
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Abstract

Azadirachta indica is an evergreen tree and has been known as a traditional medicinal plant in India. It has several beneficial properties and therapeutic effects like antibacterial, antifungal, antiviral, anthelminticand anti-inflammatory properties. Neem is indeed a ‘wonder tree’ as various constituents of neem have been used in medicine, public health, agriculture and beauty products. Innumerable studies have been done in diabetes, cancer and malaria, to name a few. Neem has been used since ages to maintain the Oro dental health, especially in our country as a substitute for toothbrush.

Keywords: Neem, bark, leak extract, neem chewing stick, dental gel, mouth rinse.
Downregulation of Bcr-Abl oncogene in Chronic Myeloid Leukemia by microRNAs

Downregulation of Bcr-Abl oncogene in Chronic Myeloid Leukemia by microRNAs

Authors:
Year: 2018, Volume: 5, Number: 4
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Abstract

The well-known myeloproliferative malignancy, chronic myeloid leukemia (CML), causes due to the formation of short and modified Philadelphia chromosome having the Bcr-Abl oncogene. Many therapeutic approaches have been made for the treatment of CML, the best one was the development of Tyrosine Kinase Inhibitors (TKIs), mainly Imatinib. But after the development of mutation against Imatinib, researchers moved towards RNA interference (RNAi) of BCR-ABL mRNA via microRNAs. In this review, we identified 105 miRNAs by Target Scan, miRbase and miRNAMap, which target the proteins of CML signaling pathway. These are selected on the basis of their constitutive activation in the Bcr-Abl positive cell lines. Targeting these proteins by miRNAs might effectively enhance chemotherapy-induced cytotoxicity in CML cells. Out of these 105 miRNAs, 21 were found to commonly effective against those proteins. These 21 microRNAs may or may not have been studied in CML cases, but have been studied in other solid or myeloid tumors. This review might be helpful in extending the studies regarding regulation of CML signaling proteins by miRNAs.

Keywords: Chronic Myeloid Leukemia (CML), MicroRNAs (miRNAs), Target Scan, miRbase, miRNAMap
Surgical management of oro - antral fistula due to dental procedures: two case reports

Surgical management of oro - antral fistula due to dental procedures: two case reports

Authors: KAO Ayekinam
Year: 2018, Volume: 5, Number: 4
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Abstract

Oro-antral fistula is one of the most frequently encountered complications after tooth extractions in the posterior maxillary. It can also be a complication following an infection involving the maxillary teeth, invasion of the sinus cavity by a cyst or carcinoma, trauma, the Caldwell-Luc operation, or implant procedures. Oro-antral fistula is an epithelised tract linking the maxillary sinus to the oral cavity if the oro-antral communication is not treated or in case of failure. Many surgical techniques have been proposed for the closure of the oro-antral fistula and the factors that should be considered for choice of each technique depend on the size of the communication, its location , time of diagnosis and health of the maxillary sinus. In order to avoid any sinus complication, the oro-antral fistula must be quickly closed.

Keywords: oro-antral fistula, Buccal fat pad flap, buccal flap.

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