Indian Journal of Research in Pharmacy and Biotechnology

Indian Journal of Research in Pharmacy and Biotechnology

Basic info

  • Publisher: Indian Journal of Research in Pharmacy and Biotechnology
  • Country of publisher: india
  • Date added to EuroPub: 2017/May/21

Subject and more

  • LCC Subject Category: Biotechnology, Pharmacy
  • Publisher's keywords: Biotechnology, Pharmacy
  • Language of fulltext: english
  • Full-text formats available: PDF

Publication charges

  • Article Processing Charges (APCs): Yes 50USD
  • Submission charges: No
  • Waiver policy for charges? No

Editorial information

Open access & licensing

  • Type of License: Other
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2013
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: None
  • Content digitally archived in: Nopolicy
  • Deposit policy registered in: Sherpa/Romeo

This journal has '510' articles

EFFECT OF METHANOLIC EXTRACT OF ADENANTHERA PAVONINA LINN ON DALTON'S ASCITIC LYMPHOMA

EFFECT OF METHANOLIC EXTRACT OF ADENANTHERA PAVONINA LINN ON DALTON'S ASCITIC LYMPHOMA

Authors: Arihara Siva Kumar G, Rajesh Kumar Javvadi1, Vinay Kumar K, Manohar Reddy E, Veera Reddy Y, Harshavardhan G, Akbar MD
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Abstract

The present study was undertaken to examine anticancer activity of Adenanthera pavonina L stem bark extract on Dalton's ascitic lymphoma (DAL) in male Swiss albino mice. Tumour was induced in mice by intraperitoneal injection of DAL cells (1 x 1000000 cells / mouse). Methanol extract of Adenanthera pavonina L (MAP) was administrated to the mice at the dose of 125 and 250 mg/kg/day, p.o. The antitumor effect of the extract was evaluated by using In-vitro cytotoxic assay; Mean survival time (MST), Tumour volume (TV), Percentage Increase in Life Span (ILS), viable and non-viable tumour cells count. The findings of this study indicate that the MAP possesses significant antitumor activity.

Keywords: Dalton's ascitic lymphoma, Tumor volume, Percentage Increase in Life Span, antitumor activity
POISONOUS HOUSEHOLD ITEMS AND THEIR SOCIAL IMPACT

POISONOUS HOUSEHOLD ITEMS AND THEIR SOCIAL IMPACT

Authors: Subhasish Chaudhuri1, Biswajit Chandra Das
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Abstract

Many of the products we use for housework, gardening and home improvement contain hazardous chemicals that endanger our health as well as pollute the environment. These poisons affect our body either immediately (acutely toxic) or over a long period of time (chronically toxic) can damage and destroy cells and chromosomal material (known to cause cancer, mutations and fetal harm). People expose those harmful chemicals in different ways- by eating, breathing, drinking and the most important exposure rotate is through skin. The person involves applying those products and farm workers are most likely to be affected. In other hand those items are uses as sniffer drugs especially by the teenagers. A quite good numbers of common products are presently abused by the young generation in the society just to enjoy the feeling of well being and also to get a quick high for a short period. Identification of those poisonous household products is necessary for awareness to handle the same. An overview of common health and safety hazards is presented.

Keywords: Poisonous household items, hazardous chemicals
DEVELOPMENT AND EVALUATION OF HIGH POROUS MOUTH DISSOLVING TABLETS CONTAINING LAMOTRIGINE COMPLEXATION

DEVELOPMENT AND EVALUATION OF HIGH POROUS MOUTH DISSOLVING TABLETS CONTAINING LAMOTRIGINE COMPLEXATION

Authors: Dipankar Das, B. K. Sridhar
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Abstract

Lamotrigine (LMG) is an Antiepileptic drug which is widely used in epilepsy. It is also used in simple and complex partial seizures and secondary generalized tonic-clonic seizures. It is poorly water soluble drug (0.17mg/ml at 250C). Thus, in the work under taken, an attempt was made to enhance the water solubility by complexation with β-cyclodextrin (1:5 molar ratios). The mouth dissolving tablet of LMG was prepared by direct compression method using different concentration of subliming agent like menthol and superdisintegrant like sodium starch glycolate. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, water absorption ratio, in vitro disintegration time and in vitro dissolution studies etc. The prepared tablets were characterized by Fourier transform infra red spectroscopy, differential scanning calorimetry, powder X-ray diffraction studies, scanning electron microscopy. The disintegration time for the complexed tablets prepared by different concentration of menthol are found to be in range of 25±2.52 to 91±3.05 seconds and the formulation which are prepared by different concentration of sodium starch glycolate are found to be in range of 30±1.00 to 95±2.52 sec. All the formulation showed almost 100 percent of drug release within 40 min. Among all the formulation, F5 prepared with 40 mg menthol and F13 prepared with 35 mg sodium starch glycolate shows faster drug release, respectively 12 min and 15 min. Further formulations were subjected to stability testing for 2 months at temperature of 40±5ºC/75±5%RH. Tablets have shown no appreciable changes with respect to physical appearance, drug content, disintegration time, and dissolution profiles.

Keywords: Lamotrigine, β-cyclodextrin, Sublimation, Super disintegrants, Mouth dissolving tablets
RECENT TRENDS IN POLYMER USE IN BIOADHESIVE DRUG DELIVERY SYSTEM

RECENT TRENDS IN POLYMER USE IN BIOADHESIVE DRUG DELIVERY SYSTEM

Authors: Nalla Chanda, Thirupathi Reddy A, B Appanna, Ch Papinaidu, D Suvarchala
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Abstract

Bioadhesion can be defined as the process by which a natural or a synthetic polymer can adhere to a biological substrate. When the biological substrate is a mucosal layer then the phenomena is known as mucoadhesion. The substrate possessing bioadhesive property can help in devising a delivery system capable of delivering a bioactive agent for a prolonged period of time at a specific delivery site. The current review provides a good insight on mucoadhesive polymers, the phenomenon of mucoadhesion and the factors which have the ability to affect the mucoadhesive properties of a polymer. The drugs which have local action or those which have maximum absorption in gastrointestinal tract require increased duration of stay in GIT. Thus, mucoadhesive dosage forms are advantageous in increasing the drug plasma concentrations and also therapeutic activity.

Keywords: Mucoadhesion, mucosa, mucoadhesive polymers, drug delivery
AN ICE-CREAM TYPE PHARMACEUTICAL FORMULATION OF PIPERAZINE HYDRATE AND ITS EVALUATION

AN ICE-CREAM TYPE PHARMACEUTICAL FORMULATION OF PIPERAZINE HYDRATE AND ITS EVALUATION

Authors: M Komala, K Hima Bindu , P Shanmugapandiyan, P Veera Swamy, R Sivakumar,
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Abstract

The main objective of this work is to develop an ice cream type pharmaceutical formulation of piperazine hydrate and a process for preparing the same to substitute for tablets and syrups. Ice cream type formulations have merits over conventional formulae in-terms of compliance, so it can be used as an improved pharmaceutical formula for children affected by helminthic infection. The in-vitro diffusion profile of the formulation was studied in pH 1.5 buffer (acidic medium) and in pH 7.8 buffer (alkaline medium) for 2 hours in each buffer medium. The release in acid medium was 23.5% maximum at the end of 2 hours. This showed that only negligible amount of drug was released in acid medium. The release in pH 7.8 buffer was found to be 80% at the first 15mins which showed an immediate on-setting action of the drug in the body system. The drug release is prolonged up to 2 hours and absorption of up to 95% of the drug within 2 hours in the intestinal tract is possible. The diffusion study results concluded that major portion of the drug was available for the body system to cure the infection of Ascariasis.

Keywords: Ice creams, In-vitro diffusion profile, helminthic infection, piperazine hydrate
DRY EMULSION: A PROMISING DOSAGE FORM TO DELIVER LIPOPHILIC DRUG MOLECULES WITH IMPROVED STABILITY AND EFFECTIVENESS

DRY EMULSION: A PROMISING DOSAGE FORM TO DELIVER LIPOPHILIC DRUG MOLECULES WITH IMPROVED STABILITY AND EFFECTIVENESS

Authors: Haritha M, Priyanka M, Abeda Aqther, Neeharika R, Pragati Kumar
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Abstract

Liquid emulsions have distinct advantages over the other oral dosage forms by improving the bio availability and by reducing the side effects, but the number of emulsion formulations currently in use are few compared with other oral dosage forms due to lack of physical - chemical and compliance problems. To overcome these problems dry emulsions are prepared. Dry emulsions are prepared by drying liquid o/w emulsions containing a solid carrier in the aqueous phase. The solid carrier provides the dry emulsions with bulk and mass. Dry emulsions are lipid based powder formulations from which an O/W emulsion can be reconstituted in-vivo or in-vitro. Dry emulsions can be prepared by spray drying, lyophilization and rotary evaporation. Unfortunately the dry emulsions were cohesive powders. The cohesiveness was reduced by addition of sucrose.

Keywords: DRY EMULSION, PROMISING DOSAGE
FORMULATION DEVELOPMENT AND EVALUATION OF LOPERAMIDE HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS

FORMULATION DEVELOPMENT AND EVALUATION OF LOPERAMIDE HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS

Authors: A Bharathi, K Mohan Guptha, Y Uma Jagannadha Rao
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Abstract

There is an increasing demand for more patient compliant dosage form and a novel method is the development of orally disintegrating tablets which dissolve or disintegrates instantly on the patient tongue or buccal mucosa. It is suited for tablets undergoing high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to minimize side effect and make it more cost effective. Loperamide hydrochloride is a drug of choice for diarrhoea. Loperamide hydrochloride has systemic bioavailability too low due to extensive hepatic first pass metabolism. Hence the main objective of the study was to formulate orally disintegrating tablets of Loperamide hydrochloride to achieve a better dissolution rate and further improving the bioavailability of the drug and to get relief from diarrhoea very quickly. Orally disintegrating tablets prepared by direct compression and using super disintegrant crosspovidone were prepared and evaluated for the pre- compression parameters such as bulk density, compressibility, angle of repose etc. The prepared batches of tablets were evaluated for hardness, weight variation, friability,drug content, disintegration time and in-vitro dissolution profile and found satisfactory. Among the 6 groups (f1, f2, f3, f4, f5, f6),formulation f4 emerged as the best formulation and showed rapid dissolution rate i.e. it releases 95% drug in 5 min.

Keywords: Loperamide hydrochloride, orally disintegrating tablets, Aspartame
FORMULATION AND EVALUATION OF ORAL CONTROLLED FLOATING TABLETS OF ANTI-ASTHAMATIC DRUG

FORMULATION AND EVALUATION OF ORAL CONTROLLED FLOATING TABLETS OF ANTI-ASTHAMATIC DRUG

Authors: Sony Yellapu, Debjith Bhowmick, Harish Gopinath, Arvind Gurram, Anusha P
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Abstract

The objective of the present research work is to formulate and evaluate oral controlled floating tablet of anti-asthmatic drug Terbutaline sulphate. The pre and post compression parameters have been studied and the results were found to be within the IP specification. The formulations F3 and F6 showed higher swelling index compared to others. In-vitro release rate studies showed that the maximum drug release was observed in F2 and F9 formulations up to 12 hrs. Optimized formula found to be stable at 45oC and 75% RH for a period of 3 month. FT-IR studies revealed that there was no interaction between drug and the polymers used. From the study it is evident that a promising controlled release floating tablets of Terbutaline sulfate can be developed to increase gastric residence time. Further detailed investigations are required to establish efficacy of these formulations and fix the required dose.

Keywords: Terbutaline sulphate, Conventional tablet, Anti-Asthmatic
HEPATOPROTECTIVE EFFECT OF LEAVES OF MADHUCA LONGIFOLIA (KOENIG) AGAINST PARACETAMOL INDUCED ACUTE LIVER DAMAGE IN RATS

HEPATOPROTECTIVE EFFECT OF LEAVES OF MADHUCA LONGIFOLIA (KOENIG) AGAINST PARACETAMOL INDUCED ACUTE LIVER DAMAGE IN RATS

Authors: Arun Kumar, Kaushik Biswas, Bhavin A, Babaria, S Ramachandra Setty
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Abstract

The present study was desined to evaluated the hepatoprotective activity of 70% ethanolic extract of leaves of Madhuca longifolia in paracetamol (2gm/kg) induced liver toxicity in albino wistar rats. The paracetamol injected rats were found to be with significantly increased level of biochemical markers like SGPT (Serum glutamate pyruvate transaminase), SGOT, (Serum glutamate oxaloacetate transaminase) ALP (alkaline phosphatases), serum bilirubin (total and direct), total cholesterol and serum triglycerides. The depleted GSH (glutathione) leves and increased lipid peroxidation indicated the involvement of free radicals in the liver toxicity. 70% ethanolic extract at the dose of 20mg/kg and 40mg/kg produced significant reduction in the serum levels of biochemical markers mentioned above. The extract also increased the levels of GSH and significantly decreased the lipid peroxidation. The results of 70% ethanolic extract were comparable with the standard silymarin. These results suggest that 70% ethanolic extract of Madhuca longifolia (Koenig) may possess the potential therapeutic value in the treatment of some liver diseases, which can be attributed to its anti-oxidant action.

Keywords: 70% extract, Madhuca longifolia, hepatoprotectve, GSH, lipid peroxidation, biochemical markers
FORMULATION, DEVELOPMENT, EVALUATION OF CALCITRIOL AND CLOBETASOL

FORMULATION, DEVELOPMENT, EVALUATION OF CALCITRIOL AND CLOBETASOL

Authors: Pasupathi A, Palanisamy P, B Jaykar, R Margret Chandira, B S Venkateswarlu
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Abstract

Psoriasis vulgaris is a common skin disorder characterized by focal formation of inflamed, raised plaques that constantly shed scales derived from excessive growth of skin epithelial cells. Prevalence of Psoriasis is 2-3 % in general population. Currently, Topical Corticosteroids remain a pivotal treatment due to their effective anti-inflammatory properties; however potential adverse effects associated with chronic application limit long-term continuous therapy. Vitamin D analogues provide another mechanism of action reducing lesions through effects on keratinocytes and on cytokine environment. A topical combination of corticosteroid & Vitamin D derivative appears to provide a balanced approach to psoriasis treatment. When Calcitriol is used in combination with topical steroids, some improvement in psoriasis treatment was observed. The main side effect of Calcitriol is skin irritation. Topical steroids Clobetasol used in conjunction with Calcitriol may lessen skin irritation. Combination reduces hazards associated with long term use of topical Corticosteroids (atrophy and rebound) as well as irritation associated with Calcipotriol. Various formulations of Calcitriol (0.0003%) and Clobetasol Propionate (0.05%) were taken for optimization in relation to ointment base, consistency, ointment stability, stability with antioxidant, stability with different preservatives, and effect of temperature of Calcitriol phase addition to bulk white petrolatum base of ointment. Observations of all formulations for physical characterization and drug release profile had shown that, all comply with the specifications of official pharmacopeias and or standard reference. It was observed that, formulation batch- F12 selected as optimized formulation of Ointment, as it fulfills all requirements of Topical ointment.

Keywords: Psoriasis vulgaris, Calcitriol (0.0003%) and Clobetasol Propionate (0.05%)
FORMULATION, OPTIMIZATION AND IN-VITRO EVALUATION OF NIFEDIPINE SUSTAINED RELEASE TABLET

FORMULATION, OPTIMIZATION AND IN-VITRO EVALUATION OF NIFEDIPINE SUSTAINED RELEASE TABLET

Authors: Pasupathi A, Palanisamy P, B Jaykar, R Margret Chandira, BSVenkateswarlu
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Abstract

The objective of the present study was to develop sustained release tablet of Nifedipine. The drug is a dihydropyridine derivative mainly indicated for the treatment of Hypertension. The drug belongs to the therapeutic classification as calcium channel blocker and antianginal. The tablets were prepared by wet granulation method.The granules were evaluated for angle of repose, bulk density, tapped density, compressibility index, and Hausner ratio. The tablets were subjected to thickness, hardness, friability, weight variations, and drug content by assay and in vitro dissolution studies. The granules showed satisfactory flow properties, compressibility index and drug content. All the tablet formulations showed acceptable pharmaceutical properties.The in-vitro drug release from Nifedipine sustained release tablet was carried out in 1.2 N HCl, and 6.8 pH phosphate buffer for 24hrs. The optimized formulation F3 showed the highest f2 (similarity factor) (f2 = 75.5) value. The drug release from the developed formulation was independent of agitational intensity. The release rate was influenced by medium, the amount of rate controlling polymer. The similarity factor, f2 was applied between the optimized formulation and the theoretical dissolution profile. The comparison of optimized formulation with marketed product gave a satisfactory release profile. The drug release data were plotted using various kinetic equations (Zero order, First order, Higuchi’s kinetics, Korsmeyer and Peppas kinetics and Hixson and Crowell kinetics) to evaluate the drug release mechanism and kinetics. The formulations were found to be stable for after 2 months of accelerated stability studies.

Keywords: sustained release tablet, Nifedipine, calcium channel blocker, rate controlling polymer, in-vitro drug release
FORMULATION AND EVALUATION OF DEXLANSOPRAZOLE DELAYED RELEASE CAPSULES

FORMULATION AND EVALUATION OF DEXLANSOPRAZOLE DELAYED RELEASE CAPSULES

Authors: Peer Basha Syed, Chakravarthi V,Venkateswarlu B,Koteswararao P, Farooq Ahmed
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Abstract

The present research work is formulation and evaluation of dexlansoprazole delayed release capsules. Dexlansoprazole is proton pump inhibitor (PPI) used in treatment of gastro esophageal reflux disease (G.E.R.D), Erosive esophagitis (E.E) and acid – related factors. In this research work various polymers like HPMC P55 S, Eudragit L 100 were used as enteric coating polymers were prepared in a fluidized bed coater (FBC). The pre-formulation studies such as solubility and compatability studies were carried out. In the formulation study of dexlansoprazole different formulation (F1 - F10) have been formulated and evaluated for acid resisitance, dissolution profile and release kinetics. The drug percentage release is more when compared with the marketed product. Stability study was done at various storage conditions and months for description, assay, water content, related substances. Mainly research work is to develop a pharmaceutically equivalent low cost quality improved and stable formulation and evaluation of dexlansoprazole delayed release capsules comparable to innovator product.

Keywords: Dexlansoprazole, HPMC P 55 S, Eudragit L 100 55, pH 6.8 Phosphate buffer, Sodium Lauryl Sulphate
DESIGN AND IN VITRO EVALUTION OF SUSTAINED RELEASE FILM COATED TABLETS OF VERAPAMIL HYDROCHLORIDE

DESIGN AND IN VITRO EVALUTION OF SUSTAINED RELEASE FILM COATED TABLETS OF VERAPAMIL HYDROCHLORIDE

Authors: BS Venkateswarlu, B Jaykar, Pasupathi A, R Margret Chandira, Palanisamy P
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Abstract

An attempt was made to formulate the sustained release tablet of verapamil hydrochloride by using the wet granulation method for the treatment of hypertension. In the present formulation the tablets releases the loading dose by immediate drug release and maintenance dose up to 15 hours by extended release. The drug excipient compatability study was carried out with HPLC method and there was no interaction found. Immediate release fraction was formulated by using croscarmellose sodium as a disintegrating agent and extended release fraction was formulated by using Hypromellose E4 as a rate controlling polymer. The granules were evaluated for pre and post compressional character which showed satisfactory results. In vitro dissolution study was carried out for 15 hrs using USP dissolution apparatus type II with 0.1 N HCl and 7.4 pH phosphate buffer as dissolution medium. From the dissolution profile, F2 & F3 values were calculated which were within the specification. Stability study was carried out for the optimized formulation at 40°C/75% RH for 1 month, the result showed that there was no significant change in physical and chemical parameter of the tablet.

Keywords: Verapamil Hydrochloride, Sustained release tablet, Hypromellose E4
EVALUATION OF ANTI-DIARRHOEAL ACTIVITY OF ETHANOLIC LEAF EXTRACT OF SCOPARIA DULCIS LINN ON WISTER ALBINO RATS

EVALUATION OF ANTI-DIARRHOEAL ACTIVITY OF ETHANOLIC LEAF EXTRACT OF SCOPARIA DULCIS LINN ON WISTER ALBINO RATS

Authors: Amitabha Dey, Ghanshyam Panigrahi, Lokesh Deb, Kh. Nongalleima, Pratap Patra
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Abstract

The objective of the study was to find out the ethanolic extract of the leaves of Scoparia dulcis Linn for antidiarrhoeal effects on Wister albino rats. The extract was evaluated for castor oil- induced diarrhoea and intestinal transit in rats by charcoal meal. S. dulcis Linn. Significantly (p<0.05) and dosedependently reduced frequency of stooling in castor oil-induced diarrhoea and intestinal motility in rats. The oral LD50 values obtained were greater than 2000mg/ kg in Wister albino mice. These findings suggest that the ethanolic extract of the leaves of S. dulcis Linn may contain some biologically active ingredients that are useful for the treatment of diarrhoea in Indian herbal traditional medicine.

Keywords: Scoparia dulcis, Antidiarrhoeal activity, Castor oil, Charcoal meal
MECHANISM OF DRUG LOADING, EVALUATION AND APPLICATIONS OF ERYTHROCYTES AS CARRIERS FOR DRUG TARGETTING

MECHANISM OF DRUG LOADING, EVALUATION AND APPLICATIONS OF ERYTHROCYTES AS CARRIERS FOR DRUG TARGETTING

Authors: Sandeep Kumar Singh, Shailesh Kumar Yadav, Ajay Kumar, Amit sankar Dutta
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Abstract

Resealed Erythrocytes are of appropriate size and shape to carry drugs. They are biocompatible and they have minimum toxic side effects. Minimum leakage can be observed before they reach the target site and they are able to carry broad spectrum of drugs. Carrier erythrocytes and resealed erythrocytes are being used for continuous implementation of safe and effective delivery of various drugs for passive and active targeting. Further optimization is required to become a routine drug delivery system which has been extended to the delivery of biopharmaceuticals and to be explored continuously regarding the potential of encapsulated erythrocytes. Resealed erythrocytes and loaded erythrocytes allow controlled drug release and increased specificity of delivery to the targeted organ. This review focus on various methods of encapsulated erythrocytes preparation, techniques of drug loading such as electroencapsulation, chemical perturbation, entrapment by endocytosis etc, mechanism of resealed erythrocyte release and evaluation resealed erythrocytes.

Keywords: Resealed erythrocytes, controlled drug release, electro-encapsulation, chemical perturbation

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