Universal Journal of Pharmaceutical Research

Universal Journal of Pharmaceutical Research

Basic info

  • Publisher: Global Institute of Pharmaceutical Education and Research
  • Country of publisher: india
  • Date added to EuroPub: 2019/Feb/24

Subject and more

  • LCC Subject Category: Medicine
  • Publisher's keywords: Pharmaceutics, Pharmacology, Pharmaceutical Chemistry, Pharmacognosy and Phytochemistry, Biopharmaceutics, Pharmaceutical Analysis, Pharmaceutical Microbiology, Pharmaceutical Biotechnology, Pharmacology and Toxicology, Clinical Pharmacy, Bioinformatics, Pharmaceutical Management, Health Care Management, Hospital Management, Biochemistry, Regulatory Affairs
  • Language of fulltext: english
  • Full-text formats available: PDF

Publication charges

  • Article Processing Charges (APCs): Yes 100 USD
  • Submission charges: No
  • Waiver policy for charges? Yes

Editorial information

Open access & licensing

  • Type of License: CC BY
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2016
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: Nopolicy
  • Deposit policy registered in: None

This journal has '151' articles

Editorial Message..

Editorial Message..

Authors: Rana Ahmed Mohammed El-Saied El-Fitiany
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Abstract

I would like to deeply congratulate all the Universal Journal of Pharmaceutical Research team for completing 3 successful years since the rise of the journal. It was an honor to join the UJPR team as a member in the Editorial Board team since 12th of October 2017. I am feeling comfort and satisfaction during my work with them as the entire team members are active, cooperative and helpful. I would like also to thank all editorial board members for providing the convenient atmosphere for raising proposals and suggestions to improve the journal quality, as consequence all the articles are having now DOI and the journal is indexed in Google scholar for example, which increase the journal articles citation. Thus, I’m very optimistic for the future of our journal as I am expecting much more progress for UJPR to be indexed in the important indexing platforms as Scopus and Thomson Reuters.

Keywords: Egypt
PRESCRIPTION PATTERN OF ANTI-HYPERTENSIVE DRUGS IN A TERTIARY CARE HOSPITAL IN KERALA AND ADHERENCE TO JNC-8 GUIDELINES

PRESCRIPTION PATTERN OF ANTI-HYPERTENSIVE DRUGS IN A TERTIARY CARE HOSPITAL IN KERALA AND ADHERENCE TO JNC-8 GUIDELINES

Authors: Thasvi Kareem, Sudha MJ, Ashkar Manakkalavalappil, Parvathy G
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Abstract

Hypertension is a leading contributor to the global burden of cardiovascular morbidity and mortality. Worldwide prevalence is continuing to increase. Treatment for hypertension is constantly evolving and many new drugs are added at rapid pace. The objective of this study is to investigate utilization pattern of antihypertensive drugs in hypertensive patients in Azeezia institute of Medical Sciences and Research and to find its adherence to JNC-8 guidelines for management of hypertension. Descriptive drug utilization study was conducted on 266 hypertensive patients for period of 3 months. Data retrieved from patient's medical record. The study included all hypertensive patients with or without co-morbidities and above 18 yrs who attended out-patient department. Following classes of antihypertensive drugs were analyzed: Angiotensin Converting Enzyme Inhibitors (ACEI), Angiotensin Receptor blockers (ARB), beta blockers, calcium channel blockers, diuretics. Out of 266 patients, 57.5% were males and 42.5% female patients indicating higher prevalence in male population. 54.5% and 42.9% of total hypertensive patients belonged to age group above 60 years and 40-60 years respectively. 59% of the total population received combination therapy.40.9% received monotherapy. ACEI/ARB was mostly prescribed which is in adherence to JNC-8 guidelines which recommends the use of ACEI/ARB as the first choice of drug. Hypertension is more prevalent in males than in females. ACEI/ARB are the most frequently prescribed classes of drugs alone or in combination, supporting the medication adherence to JNC-8 guidelines.

Keywords: Antihypertensive drugs, drug utilization, hypertension, JNC-8 guidelines, prescription pattern
PREVALENCE OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AT A PRIVATE HOSPITAL IN SANA'A, YEMEN

PREVALENCE OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AT A PRIVATE HOSPITAL IN SANA'A, YEMEN

Authors: Ali Alyahawi, Ali Alkaf, Abdul Monem Alhomidi
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Abstract

Methicillin resistant Staphylococcus aureus (MRSA) strains are common causes of nosocomial infections and are associated with increased morbidity and mortality. In addition, the antibiotic resistance for MRSA is a major concern in clinical practice. To study the prevalence and the antimicrobial susceptibility pattern of MRSA isolates from patients in a private hospital. The study was performed at a private hospital in Sana’a, Yemen. All the patients' samples from January, 2017 to December, 2017 were included. All isolates from inpatients’ clinical specimens (mainly respiratory secretion, pus, urine, and blood) were collected and standard isolation procedures were applied to all the samples. The records were taken from the microbiology department. Antibiotic susceptibility testing was done by Kirby Bauer's Disc diffusion technique, following the national committee for clinical laboratory standards. The antimicrobial susceptibility patterns of all the MRSA strains were studied against several antibiotics. A total of 2079 samples were gathered during the study period. Among them, 199 strains of Staphylococcus aureus were isolated. A majority of Staphylococcus aureus isolates were from pus specimen (n=81/199; 40.7%). MRSA prevalence among the patients was 17.6 % (n=35/199; 17.6). Highest proportion of MRSA was in ICU and surgical departments about 29% of all MRSA isolates. A majority of MRSA isolates were from sputum specimen (n=18/35; 51.4%). The study findings showed that MRSA isolates had the highest frequency of resistant (100%) to levofloxacin and amoxicillin/ clavulinic acid, followed by ciprofloxacin 97%, gentamicin and ampicillin/ sulbactam 94 %, cefuroxime 91 %, moxifloxacin 76%, erythromycin 71.5%, clindamycin 70.5%, and imipenem 55%. The highest frequency of sensitivity (100%) was observed with linezolide, vancomycin, and trimethoprim/ sulfamethoxazole. MRSA isolates were highly susceptible to newer drugs such as linezolid and to vancomycin which is not a commonly prescribed drug due to the higher nephrotoxic antibiotic. A more careful monitoring for use of broad-spectrum antibiotics should be instituted.

Keywords: Antimicrobial susceptibility, MRSA, prevalence, vancomycin
TREATMENT OF PATIENTS WITH ADVANCED CANCER FOLLOWING CHEMOTHERAPY AND TRADITIONAL MEDICINE - LONG TERM FOLLOW UP OF 75 CASES

TREATMENT OF PATIENTS WITH ADVANCED CANCER FOLLOWING CHEMOTHERAPY AND TRADITIONAL MEDICINE - LONG TERM FOLLOW UP OF 75 CASES

Authors: George Zhu
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Abstract

Traditional systems of medicine all over the world even traditional medicine and cancer have been using plants and plants products for therapeutic intention. The purpose of these retrospective trials is to assess the clinical efficacy of chemotherapy in conjunction with TCM for a broad variety of cancers. 75 patients with available cancers were concluded in the study during September1993 – May 2018.The sex ratio of male: female was 50:25 respectively. The mean age at onset was 46.9 years(range 10-79 years. All patients were treated with different dosage of various chemotherapy in combination with TCM or traditional medicine alone. The basic chemotherapeutic regimen consisted of vincristine(VCR,1-2mg/ week)、cyclophosphamide(CTX,200-1,000mg/ week)、mitomycin C(MMC,2-4mg/week) and 5-fluorouracil(5-Fu,250-500mg/ day).In addition, according to patient condition, the additional drug doxorubicin(ADM, 20mg/ week)in lymphoma and metastatic breast cancer, demethylcantharidin in liver cancer and cisplatin (DDP) or interleukin-2(PHA)or gefitinib in lung cancer. The detail prescription of TCM varied among a broad variety of carcinomas. The criteria of complete remission(CR)and/or partial remission(PR)is according to the rules where physicians have in common with in clinics. In 75 cases, the CR was obtained in 33(44%) advanced cancers, a short CR in 11(14.7%) cases, PR in 25 (33.3%) cancers, stable disease in 6 cases. In differential types of 20 patients over ten years, lymphoma occupied 8 cases (40%). As to approach to the schedule of drug administration, 16 lymphoma obtained CR via COMA (CTX, VCR, MMC, ADM) regimen and TCM or antibiotics and immunotherapy. Five advanced gastric cancer were successfully treated using MFC and cinobufacini/ cantharidin, and TCM. In follow up, one HCC accompanied with colon polyps obtained CR via hepatectomy and targeting oncogenic receptor tyrosine kinase inhibitor sorafenib. Among two lung cancer, one female with metastatic lung cancer was given targeting oncogenic receptor EGFR gefitinib therapy after the combination chemotherapy, which was stable disease for 8+months.CR can also achieved in one advanced cholangicarcinoma and one advanced gallbladder cancer through major protocol of TCM and the addition of small dosage of chemotherapy. Thyroid cancer was placed on the primary use of TCM. The crude herbs consisted of sargassum, tangle, Oyster(mussels), Poria cocos, Ophiopogon japonicus, Prunella vulgaris, Taraxacum, Scrophularia ningpoensis, Cremastra appendiculata, Trichosanthes Kirilowii, Sophora subprostrata, Houttuynia cordata, Scutellaria barbata d. don and Oldenlandia diffusa roxb. Among those long-term survivors, 31 carcinomas obtained in disease-free survival over 5years, 20 cancers were survival over 10years, the longest four patients over 25 years. In this study, it was experienced that a CR was a pivotal influencing factor in those longest survival patients, and traditional medicine was also recommended. Down regulating oncogenic receptors may be useful paradigm and perspective in currently the third line setting of clinical target therapy and in rendering our better understanding of cancer biology.

Keywords: Cancer chemotherapy, target therapy, traditional medicine
ANTIHYPERGLYCEMIC AND ANTI-OXIDANT POTENTIAL OF ETHANOL EXTRACT OF VITEX THYRSIFLORA LEAVES ON DIABETIC RATS

ANTIHYPERGLYCEMIC AND ANTI-OXIDANT POTENTIAL OF ETHANOL EXTRACT OF VITEX THYRSIFLORA LEAVES ON DIABETIC RATS

Authors: Theodora Kopa Kowa, Nyemb Nyunaï, Thierry Gilbert Nkoulou Tabi
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Abstract

The antihyperglycemic effect of an ethanol extract of Vitex thyrsiflora leaves was investigated in normal male rats and streptozotocin‐induced diabetic male rats and its antioxidant potential was evaluated. After preparation of the extract, it was subjected to a phytochemistry screening, and tested on male rats made hyperglycemic in the Oral Glucose Tolerance Test (OGTT) and in streptozotocin diabetic rats. Glibenclamide (10 mg/kg) was served as a positive control in both experiments. During both experiments, the extract was tested at 200 and 300 mg/kg. The evaluation of the antioxidant potential was done through the determination of the Total Polyphenols and Total Flavonoid Contents, and by using the Ferric Reducing Antioxidant Power assay and the Free radical scavenging activity on DPPH method. The results show that the extract contains alkaloids, flavonoids, steroids, saponins and phenolic compounds. The test on hyperglycemic rats in OGTT showed that, the extract was effective (at a dose of 200 mg/kg) to significantly decreased glucose-induced hyperglycemia (**p ˂ 0.01). The extract was ineffective on streptozotocin‐induced diabetic rats. The study of the antioxidant potential showed that, polyphenols and flavonoids increase with the concentration of the extracts. IC50 value was found to be 65.97, based on the log (inhibitor) vs. normalized response-Variable slope. FRAP appears to be significantly highly correlated with total polyphenols content and total flavonoids content. This shows that the ethanol extract of V. thyrsiflora leaves could be served to prevent acute hyperglycema, but not a chronic hyperglycemic state.

Keywords: antihyperglycemic, antioxidant, diabetic rats, Vitex thyrsiflora
THE EFFECT OF HOSPITAL MANAGERS' SUCCESSION PLANNING ON ORGANIZATIONAL PERFORMANCE: A CASE STUDY OF SHOUSHTARI MATERNITY HOSPITAL IN SHIRAZ IN 2017

THE EFFECT OF HOSPITAL MANAGERS' SUCCESSION PLANNING ON ORGANIZATIONAL PERFORMANCE: A CASE STUDY OF SHOUSHTARI MATERNITY HOSPITAL IN SHIRAZ IN 2017

Authors: Fatemeh Azizpour, Shaghayegh Vahdat, Rasool Keshtkar
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Abstract

Widespread and rapid changes that have been created in current organizations, have led to feel lack of managers with skill for key jobs of organization and hence about the importance of succession planning in organizations be as a fundamental and vital agent should be related to strategic goals of the organization and be taken from organization’s strategy and directly involves managers of line. Actually, it can be said that succession is the second important issue that current organizations are faced it. In this regard, this investigation proceeds to the investigation of the effect of hospital managers’ succession planning on Shoushtari Maternity Hospital in Shiraz in 2017. Statistical sample of the study was chosen by random method and by using Cochran formula among 240 of personnel in the hospital. Hypotheses of the study were investigated by using correlation test and regression by using SPSS software. The results in studied sample showed that succession planning has positive and meaningful effect on criteria of organizational performance (ability of employees, clarification of organizational duties, to help employees, encouragement of personnel, evaluation of personnel, increase in the credit of employees and improvement of organization’s environment).

Keywords: Organizational performance, Shoushtari Maternity Hospital in Shiraz, Succession planning
PREVALENCE OF HELICOBACTER PYLORI AMONG ASYMPTOMATIC POPULATIONS IN SANA'A, YEMEN

PREVALENCE OF HELICOBACTER PYLORI AMONG ASYMPTOMATIC POPULATIONS IN SANA'A, YEMEN

Authors: Ali Alyahawi, Ali Alkaf, Samar Alzaghrori
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Abstract

Helicobacter pylori consider the most important cause of chronic gastritis and also the most important etiological factor responsible for the duodenal and gastric ulcer and have an important role in the pathogenesis of gastric cancer. The aim of the present study to know the prevalence of H. pylori among the khat chewing adults in compared to non-khat chewing among asymptomatic populations. A total of 82 healthy subjects were screened to find out the prevalence of Helicobacter pylori using stool antigen card test during the period started in 16 April 2018 and ending in 8 May 2018 in Sana'a, Yemen. Predesigned questionnaire was used to collect information such as age, sex, education status, khat chewing, smoking, tobacco chewing, occupation, and tests results all above data were recorded for each subject. Patients who had taken proton pump inhibitors or antibiotic for a month prior to study were excluded. Out of these 82 asymptomatic individuals, 36 were found positive for Helicobacter pylori by the test, giving a prevalence of 43.9 %. A prevalence of 26.9 % (62.9 % of khat chewing) was khat chewing individuals and it had statistically significant difference. A prevalence of 14.6 % was seen among cigarette smoking participants. The present study revealed substantial prevalence of Helicobacter pylori in khat chewing healthy subjects. A higher prevalence of Helicobacter pylori seen in these subjects may be contributed to khat chewing. Identification of khat chewing populations, who do not show symptoms of Helicobacter pylori infection, is essential for controlling the infection and it still remains a challenge for the clinicians.

Keywords: Asymptomatic, H. pylori, khat chewing, prevalence, risk factors, stool antigen test
ANTIMICROBIALS SELF MEDICATION AMONG PARAMEDICAL STUDENTS IN A NIGERIAN UNIVERSITY

ANTIMICROBIALS SELF MEDICATION AMONG PARAMEDICAL STUDENTS IN A NIGERIAN UNIVERSITY

Authors: Muhammad Tukur Umar, Aluefua Omobhude Fidelis
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Abstract

Self-medication refers to selection and use of medicines by individuals to treat self-recognized illness and symptoms. It is widely practiced globally and often regarded as part of self-care. Though, unlike the other elements of self-care, it acts as a double-edged sword with the ability to do good as well as exposure to hazards because it employs use of drugs. The objective of this study was to assess prevalence of antibiotic self-medication among paramedical students of Usmanu Danfodiyo Sokoto, Nigeria. It was questionnaire-based, cross-sectional study involving undergraduate paramedical students in a Nigerian University. Participants were selected by multistage sampling technique and data generated was analyzed using SPSS version 20. Majority of the respondents were males and singles, 64(68%) and 84(89.4%) respectively. Age ranged 18-25 years for majority of respondents, 87(92.6%). Eighty one point nine percent self-medicate with antimicrobials and penicillin was the most used antibiotic group 58(61.7%), and among the penicillin group, amoxicillin was the commonly used, 17(18.1%). There was no statistically significant association between gender, marital status and course of study with self-medication (X1=0.06, P=0.81; X1=0.028, P=0.87 and X3=2.28, P=0.52 respectively). Conclusion: A high proportion of self-medication with antimicrobials was observed among the respondents of the study. However there was no statistically significant association of the medication with gender, marital status or course of study.

Keywords: Antimicrobials, Nigeria, paramedical students, self-medication, University
PREVALENCE, ANTIMICROBIAL SUSCEPTIBILITY PATTERN AND RISK FACTORS OF MRSA ISOLATED FROM CLINICAL SPECIMENS AMONG MILITARY PATIENTS AT 48 MEDICAL COMPOUND IN SANA'A CITY-YEMEN

PREVALENCE, ANTIMICROBIAL SUSCEPTIBILITY PATTERN AND RISK FACTORS OF MRSA ISOLATED FROM CLINICAL SPECIMENS AMONG MILITARY PATIENTS AT 48 MEDICAL COMPOUND IN SANA'A CITY-YEMEN

Authors: Ahmed Mohammed Ali Al-Safani, Hassan A. Al-Shamahy, Khaled A. Al-Moyed
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Abstract

Methicillin-resistant strains of S. aureus evolved in the 1970 and have troubled hospitals worldwide with persistent infections in patients. The objectives of this study were to determine the prevalence, antimicrobial susceptibility pattern and risk factors of MRSA isolated from clinical specimens among military patients at 48 Medical Compound in Sana'a city - Yemen. The study included 233 patients of whom suffering from Staphylococcus aureus infections. Specimens and data collected from November 2016 to November 2017. Standard methods of isolation and identifications were used to isolate bacteria in pours culture then Staphylococcus aureus were identifying using standard cultural techniques. MRSA was determined by the disc diffusion method to oxacillin and antimicrobial susceptibility testing was performed by the disc diffusion method for selected antibiotics. The prevalence rate of MRSA was 19.3% and there was significant association between MRSA and older age patients, and surgical site infections. There was higher rate of antibiotics resistant for tested antibiotics in MRSA isolates comparing with lower rate of antibiotics resistant in MSSA. 60% of the MRSA isolates were resistant to vancomycin. They were also susceptible to erythromycin and rifampicin (100%), but showed resistance to Cotrimoxazole and Gentamycine. In conclusion, the emergence of S. aureus isolates resistant to vancomycin and other wide range of antibiotics have raised MRSA in Yemen into a multi-drug-resistant ‘Superbug”, making it more and more dangerous than ever in our hospital environments. Regular surveillance of hospital associated infections and monitoring antibiotic sensitivity pattern and strict drug policy for antibiotics used within and outside the hospital environments are recommend.

Keywords: MRSA, MSSA, MDR, Superbug, Sana'a city, Yemen
EVALUATION OF ANTIDIABETIC DRUG ALOGLIPTIN FOR THE TREATMENT OF INFLAMMATION IN RATS

EVALUATION OF ANTIDIABETIC DRUG ALOGLIPTIN FOR THE TREATMENT OF INFLAMMATION IN RATS

Authors: Mohd. Fasih Ahmad, Anup Pradhan, D. J. Mani Babu
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Abstract

The present study was planned to evaluate the Alogliptin (Anti diabetic drug) for the treatment of inflammation in experimental models in rats. 5 groups of wister rats of either sex weighing 180- 220 g, selected for the study of 3 animal model were kept at ambient temperature of 28±2°C and relative humidity of 45 to 55% with a 12:12 h light/dark cycle. The animals were fasted for 12 h before commencing the experiment with water ad libitum. Fasting was continued till completion of the experiment. Group A was served as normal toxicant control treated with toxicant Carrageenan (model 1) and Histamine (model 2), group B with Ibuprofen (40 mg/ kg p.o.) served as standard, groups C, D and E administered with Alogliptin (low, medium and high doses p.o) respectively in each model. The Groups B, C, D and E were administered with 0.1 ml of 1% w/v of carrageenan in model 1,Histamine in model 2 into sub plantar region of right hind paw of rats 1 h after the administration of Ibuprofen/ Alogliptin. Immediately thereafter the oedema volumes of the injected paws were measured plethysmographically at prefixed time intervals. The Alogliptin with three selected doses i.e. 1, 2 and 3 mg/kg/day have exhibited a significant reduction in paw oedema volume at 4th h in carrageenan 36.92%, 51.49%, 65.46% and histamine 27.41%, 48.24%, 69.07% respectively. Ibuprofen (40 mg/kg) was used as standard reference thus standard drug has exhibited time dependent reduction in oedema volume. The results of recent studies suggest that dipeptidyl-peptidase-4 inhibitors (Alogliptin) have anti inflammatory effect on experimental models in rats.

Keywords: Alogliptin, anti inflammatory, dipeptidyl-peptidase-4, carrageenan, histamine
EXAMINING THE IMPACT OF ACCESS TO HEALTHCARE INFORMATION IN PROVIDING SERVICE IN HOSPITAL LEVEL OF HORMOZGAN PROVINCE

EXAMINING THE IMPACT OF ACCESS TO HEALTHCARE INFORMATION IN PROVIDING SERVICE IN HOSPITAL LEVEL OF HORMOZGAN PROVINCE

Authors: Parisa Zareipour, Abbas Yazdanpanah, Somayeh Hessam
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Abstract

Examining the impact of access to healthcare information in providing service in hospital level was performed in Hormozgan province. The study is applied in objective respect. The statistical population of this study includes managers and employees of private hospitals of Hormozgan province who are 3240 persons that based on Morgan sample content table, 380 persons were specified as research sample. The questionnaire has been adjusted based on 5-value Likert scale. For analysis of collected data, Pierson correlation coefficient test using SPSS software version 18 and structural equations approach (pathway analysis) using AMOS software version 20 has examined and tested the research hypotheses. There is a positive and direct relation between access to healthcare information and providing services with correlation coefficient of 0.712. The results structural equation showed that access to healthcare information with pathway factor of 0.82 influences providing service. Therefore, with healthcare information it is suggested that topics relating to providing services to be noticed by authorities.

Keywords: Healthcare information, hospital, providing service
Editorial.

Editorial.

Authors: Dr. U. S. Mahadeva Rao
Editorial. 2019/Feb/24
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Abstract

It is great honor and privilege for me to be appointed as Member - Editorial Board, Universal Journal of Pharmaceutical Research (UJPR). My heartiest salutations to Prof. Dr. Kapil Kumar, Editor-in-Chief and the other board members for their accomplishment of today through their hard work and persistence. Indeed, UJPR is now recognized as an international rather than a domestic journal with a considerable proportion of manuscripts being contributed from outside the country. UJPR will continue to adhere to its original philosophy of promoting the sharing of basic medical science experience by our members. I believe that the most critical components of any scientific journal's success are the submission of high-quality manuscripts, the dedication of members of its editorial board, and excellence of those reviewing the manuscripts. We will take utmost care for rigorous peer review of all submitted manuscripts to accept only quality contents without any fringe of conflict for publication. I will take this opportunity to appeal to all authors to prepare their manuscripts strictly according to journal instructions so as to avoid any undue delay in its editorial processing and disappointment of rejection. Now we are in the epoch of Cross disciplinary research based publications within the (preclinical) boulevards which usually assimilates information, data, techniques, tools, perspectives, concepts and / or theories from two or more disciplines of focused knowledge to progress rudimentary understanding or to decipher glitches whose solutions are outside the scope of a single discipline or area of research practice. Interdisciplinarians publish the manuscripts by mixing the best elements of disciplinary insights by crossing their parent discipline in order to generate a more wide-ranging appreciation of the issue at hand. Interdisciplinary publication allows for the synthesis of ideas and the synthesis of characteristics from many fields. Hopefully, UJPR Chief with support from editorial ­team will strive to generate an impact factor for which we invite submission of more original articles and citation of relevant literature published in this journal in your future publications.

Keywords: Malaysia
Editorial..

Editorial..

Authors: Dr. U. S. Mahadeva Rao
Editorial.. 2019/Feb/24
( 0 downloads)
Abstract

It is great honor and privilege for me to be appointed as Member - Editorial Board, Universal Journal of Pharmaceutical Research (UJPR). My heartiest salutations to Prof. Dr. Kapil Kumar, Editor-in-Chief and the other board members for their accomplishment of today through their hard work and persistence. Indeed, UJPR is now recognized as an international rather than a domestic journal with a considerable proportion of manuscripts being contributed from outside the country. UJPR will continue to adhere to its original philosophy of promoting the sharing of basic medical science experience by our members. I believe that the most critical components of any scientific journal's success are the submission of high-quality manuscripts, the dedication of members of its editorial board, and excellence of those reviewing the manuscripts. We will take utmost care for rigorous peer review of all submitted manuscripts to accept only quality contents without any fringe of conflict for publication. I will take this opportunity to appeal to all authors to prepare their manuscripts strictly according to journal instructions so as to avoid any undue delay in its editorial processing and disappointment of rejection. Now we are in the epoch of Cross disciplinary research based publications within the (preclinical) boulevards which usually assimilates information, data, techniques, tools, perspectives, concepts and / or theories from two or more disciplines of focused knowledge to progress rudimentary understanding or to decipher glitches whose solutions are outside the scope of a single discipline or area of research practice. Interdisciplinarians publish the manuscripts by mixing the best elements of disciplinary insights by crossing their parent discipline in order to generate a more wide-ranging appreciation of the issue at hand. Interdisciplinary publication allows for the synthesis of ideas and the synthesis of characteristics from many fields. Hopefully, UJPR Chief with support from editorial ­team will strive to generate an impact factor for which we invite submission of more original articles and citation of relevant literature published in this journal in your future publications.

Keywords: Malaysia
EVALUATION OF ANTIBACTERIAL RESISTANCE OF BIOFILM FORMS OF AVIAN SALMONELLA GALLINARUM TO FLUOROQUINOLONES

EVALUATION OF ANTIBACTERIAL RESISTANCE OF BIOFILM FORMS OF AVIAN SALMONELLA GALLINARUM TO FLUOROQUINOLONES

Authors: Kumar Kamashi, Mr. Honnegowda, Mayanna Asha, Chandrakala Ms.
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Abstract

Antimicrobial resistance is a growing concern worldwide. The indiscriminate use of antibiotics for a period of time has led to the emergence of antibiotic resistance in pathogenic bacteria. The present study was designed to evaluate the antibacterial efficacy of fluoroquinolone drugs, ciprofloxacin, enrofloxacin, moxifloxacin, sparfloxacin, norfloxacin, pefloxacin and ofloxacin against avian Salmonella gallinarum bacterial biofilms. The study parameters, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and biofilm elimination concentration (BEC) were determined on days 1, 3, 7, 10, 14 and 20 post inoculation for the planktonic (free) and biofilm cells of S. gallinarum by macro broth dilution method. The MIC and MBC values determined on days 1, 3, 7, 10, 14 and 20 for each of the fluoroquinolone drugs against the planktonic and biofilm forms of avian S. gallinarum were found to be non-significant. BEC values determined against the biofilm forms of S. gallinarum during the study period were found to be non-significant among the tested fluoroquinolones. The results of the present study demonstrated that fluoroquinolone drugs were effective in vitro against both the planktonic and biofilm forms of avian S. gallinarum.

Keywords: Antibiotic resistance, biofilm, biofilm elimination concentration (BEC), fluoroquinolones, minimum bactericidal concentration (MBC), minimum inhibitory concentration (MIC), S. gallinarum
PREVALENCE AND ASSOCIATED FACTORS OF ORAL NON-CANDIDA ALBICANS CANDIDA CARRIAGE IN DENTURE WEARERS IN SANA'A CITY- YEMEN

PREVALENCE AND ASSOCIATED FACTORS OF ORAL NON-CANDIDA ALBICANS CANDIDA CARRIAGE IN DENTURE WEARERS IN SANA'A CITY- YEMEN

Authors: Khaled Abdulsalam Al-Haddad, Omar Ahmed Esma’il Al-dossary, Hassan A. Al-Shamahy
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Abstract

The objective of this study was to contrast the prevalence and species of colonization of Non-Candida albicans (NCAC) in the oral cavity of denture wearers and non-denture wearers; also asses associated risk factors of their colonization. A total of 208 subjects were studied: 104 denture wearers and 104 non-denture wearers, matched by age, sex, comprised the experimental control groups, respectively. Each subject was instructed to perform oral rinsing using a phosphate-buffered saline solution, which was expectorated processed for the recovery of Candida species on on Sabouraud dextrose agar. Isolates were identified by culturing on chromogenic Candida agar noting species-specific colony characteristics. There was a significant oral carriage rate of NCAC among denture wearers (5.83% versus 11.1% in controls) with associated risk factor (5.4) (PV<0.001). The most common isolated NCAC were C. Krusi C.tropicalis with significant OR (5.5 4.7 respectively). When co-infections were considered, there was highly significant association of C. albicans + C. krusi oral colonization in cases (OR=4.56, PV<0.001). There was a significant oral carriage rate of NCAC among male denture wearers (36.9%, OR=6.6, PV˂0.001). In addition, there was a significant rate of NCAC colonization with complete denture (rate= 50%, OR=2.4, PV= 0.02). While no significant increase associated with colonization of NCAC with partial, acrylic /or chrome cobalt denture. Based on the results of this study ability of NCAC were greater in denture wearers than non-denture wearers, also greater risk of NCAC were found with males, older ages, complete denture.

Keywords: carriage, denture, Non-Candida albicans andida (NCAC), prevalence

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